The most interesting part here is that the features can be combined.

Here are a-little-time-wasting steps :

1. Open the document you want to print
2. Go to Menu Bar → File → Print to show up the printing pane or using keystrokes Command-P should save you lots of time
3. Change the option bar under Presets to Layout
4. Click on the Pages per Sheet and Mac will let you choose, 1, 2, 4, 6, 9, or 16 pages per sheet

The Combination Goes Here

If you choose Pages per Sheet to 4, then Preview the result, after that you choose again File → Print and set again Pages per Sheet to 4, you will get Pages per Sheet of 16. Can you see the combination? You can do it again, again and again as many times as it's appropriate for printing your document. This is not magic, your text will become smaller as the Pages per Sheet goes larger.